If there is a family history of this disease, genetic testing lets parents know whether their children could have an increased risk of retinoblastoma. Hence, medical care is planned with time.
For example, eye exams and check-ups may begin soon after birth or even before a baby is born.
Therefore, retinoblastoma may be diagnosed early on when the tumor is small, increasing the chances for cure and vision preservation.
Intra-Arterial and Intra-Vitreous Chemotherapy
Retinoblastoma that has spread from the eye to surrounding tissues or other parts of the body is called extraocular. This is rare but can affect the brain, spinal cord, bone marrow, or lymph nodes.
Extraocular retinoblastoma may need aggressive treatment, such as radiation, chemotherapy, and a bone marrow transplant.
RETINOBLASTOMA SPECIALISTS AT SANT JOAN DE DÉU CHILDREN’S HOSPITAL (BARCELONA, SPAIN)
Bibliography – More recent publications:
Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01 Correa G, Catalá-Mora J, Mora J, Chantada GL. Sci Transl Med. 2019 Jan 23
Global Retinoblastoma Presentation and Analysis by National Income Level. JAMA Oncol. 2020 May
Treatment of Nonmetastatic Unilateral Retinoblastoma in Children. Catala-Mora J, Chantada GL. JAMA Ophthalmol. 2018
Intra-arterial chemotherapy for retinoblastoma. Challenges of a prospective study. Català J, Mora J. Acta Ophthalmol. 2014 May
Axenfeld-Rieger ocular anomaly and retinoblastoma caused by constitutional chromosome 13q deletion. Mora J, Catala J. Pediatr Blood Cancer. 2010
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